GSC, which was originally known as the Girl Scout Cookies strain, was first bred by Northern California's Cookie Family sometime about 2012. A Sativa-leaning hybrid cross between a cutting of and the breeder’s own F1 Durban Poison strain, GSC produces a plant with multiple branches and a powerful flower.

The strain has a short stature that is common on strains with Indica lineage and is known for its tight internodal structure, which creates its iconic spear-shaped flowers with lavender calyxes. The most popular phenotype produced by the first batch of GSC seeds was .

GSC has taken home several High Times Cannabis Cup awards since it was first propagated — including a first-place trophy for Best Hybrid at the 2013 Southern California Cannabis Cup.